Description

4-Nitrophenyl Chlorothioformate is a versatile and highly reactive chemical intermediate primarily used in organic synthesis. Its value lies in its role as a key building block for introducing protected thiol or thiocarbonate functionalities into more complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of prodrugs, enzyme inhibitors, and other bioactive molecules containing thioester or thiocarbonate linkages.
• Peptide Chemistry: Used as a coupling agent or protecting group reagent for cysteine and other sulfur-containing amino acids during solid-phase and solution-phase peptide synthesis.
• Polymer Modification: Serves as a functional monomer or cross-linking agent for creating polymers with specific thiol-reactive sites for advanced material science applications.
• Agrochemical Synthesis: Employed in the production of herbicides, fungicides, and insecticides where the thiocarbonate moiety is integral to the compound's activity.
• Bioconjugation: Facilitates the site-specific labeling of proteins, antibodies, and other biomolecules for diagnostic and therapeutic applications.
• Chemical Research: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and creating novel heterocyclic compounds.

Basic Information

Product Name	4-Nitrophenyl Chlorothioformate
CAS No.	1132-69-0
Molecular Formula	C7H4ClNO3S
Molecular Weight	217.63 g/mol
Synonyms	p-Nitrophenyl Chlorothioformate; 4-Nitrophenyl Chlorothionoformate; Chlorothioformic Acid 4-Nitrophenyl Ester; 4-Nitrophenyl Chlorosulfenylformate; 1-Nitro-4-(chlorothioformyloxy)benzene; NSC 403121; p-Nitrophenyl Chlorosulfenylformate; 4-Nitrophenyl Chlorosulfenylformate
EINECS	214-489-9

Quality Control

Our 4-Nitrophenyl Chlorothioformate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its reactive nature, it should be stored under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.