Description

3-(4-Bromophenyl)Propenoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester is a specialized organophosphorus compound featuring a brominated phenyl core, serving as a versatile building block in advanced organic synthesis. Its molecular architecture makes it a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromophenyl and phosphonate functionalities into their target structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators that require the bromophenyl phosphonate moiety for biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized phosphonate-based ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers and polymers for creating advanced materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized to develop activity-based probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Cross-Coupling Reactions: Acts as a substrate in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to form complex biaryl systems.

Basic Information

Product Name	3-(4-Bromophenyl)Propenoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester
CAS No.	37176-94-6
Molecular Formula	C15H20BrO5P
Molecular Weight	391.20 g/mol
Synonyms	Diethyl (2-Ethoxy-2-oxo-1-(4-bromophenyl)ethenyl)phosphonate; Ethyl 2-(Diethoxyphosphinyl)-3-(4-bromophenyl)propenoate; (4-Bromobenzylidene)malonic Acid Diethyl Ester Phosphonate; Diethyl [(4-Bromobenzylidene)(ethoxycarbonyl)methyl]phosphonate; 2-(Diethoxyphosphoryl)-3-(4-bromophenyl)acrylic Acid Ethyl Ester; Phosphonic acid, P-[(4-bromophenyl)methylene]-, diethyl ester, ethyl ester; Diethyl (1-Ethoxycarbonyl-2-(4-bromophenyl)vinyl)phosphonate
EINECS	Contact for details

Quality Control

Our 3-(4-Bromophenyl)Propenoic Acid, 2-(Diethoxyphosphinyl)-, Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.