Description

2-o-Methylthymidine is a chemically modified nucleoside derivative, serving as a critical building block in oligonucleotide synthesis and pharmaceutical research. Its primary value lies in its role as a key intermediate for the development of novel therapeutic agents, including antisense oligonucleotides and prodrugs. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require reliable, high-quality raw materials for advanced drug discovery and development programs.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense Therapy Development: Used in the research and production of antisense oligonucleotides designed to target specific mRNA sequences.
• Prodrug Synthesis: Acts as an intermediate in creating nucleoside analog prodrugs for antiviral and anticancer applications.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and the design of new bioactive molecules.
• Biochemical Tool Development: Incorporated into probes and substrates for studying enzyme mechanisms, such as those of polymerases and nucleases.
• Pharmaceutical Intermediates: Serves as a key starting material in multi-step synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-o-Methylthymidine
CAS No.	37085-48-6
Molecular Formula	C11H16N2O5
Molecular Weight	256.26 g/mol
Synonyms	2'-O-Methylthymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-methoxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-OMe-Thd; Thymidine, 2'-O-methyl-; 2'-Methoxy-2'-deoxythymidine; 2'-O-Methyl-2'-deoxythymidine; 5-Methyl-2'-O-methyluridine
EINECS	Contact for details

Quality Control

Our 2-o-Methylthymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the stringent requirements for pharmaceutical research and GMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.