Description

Cytidine, 2'-Acetate CAS NO 36963-55-0 is a chemically modified nucleoside derivative where an acetyl group is introduced at the 2'-hydroxyl position of the ribose sugar. This modification is crucial for research and development in nucleic acid chemistry, offering a protected intermediate for the synthesis of oligonucleotides and other bioactive molecules. It serves as a valuable building block for pharmaceutical, biotechnology, and academic laboratories focused on nucleoside-based drug discovery, antisense technology, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key starting material or protected intermediate in the synthesis of novel nucleoside analogs and prodrugs for antiviral and anticancer applications.
• Oligonucleotide Synthesis: Used as a monomeric building block in solid-phase synthesis to create modified RNA or DNA strands for research and therapeutic purposes.
• Biochemical Research: Employed in enzymatic studies and metabolic pathway analysis to investigate the role of modified nucleosides.
• Antisense & RNAi Technology: A precursor for creating stabilized oligonucleotides used in gene silencing and therapeutic RNA molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Academic & R&D: Fundamental reagent for exploring new synthetic routes and studying the structure-activity relationships of nucleosides.

Basic Information

Product Name	Cytidine, 2'-Acetate
CAS No.	36963-55-0
Molecular Formula	C11H15N3O5
Molecular Weight	269.25 g/mol
Synonyms	2'-O-Acetylcytidine; 1-[(2R,3R,4R,5R)-3-Acetyloxy-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-aminopyrimidin-2-one; Cytidine 2'-acetate; 2'-Acetylcytidine; 2'-O-Acetylcytidine; N4-Amino-1-(2-O-acetyl-β-D-ribofuranosyl)-2(1H)-pyrimidinone; 2'-Ac-Cytidine
EINECS	Contact for details

Quality Control

Our Cytidine, 2'-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements. Specifications are designed to meet the high standards of pharmaceutical and biotechnology applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.