Description

3-Benzyloxy-2,2-Dimethylpropionyl Chloride is a high-purity, reactive acyl chloride intermediate essential for advanced organic synthesis. Its value lies in its ability to efficiently introduce the 3-benzyloxy-2,2-dimethylpropionyl moiety, a key building block for creating complex molecules with specific steric and functional properties. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active pharmaceutical ingredients (APIs), crop protection agents, and novel materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and process development.
• Peptide Mimetics & Prodrug Synthesis: Used to acylate amino groups or hydroxyl groups to create peptide analogs or prodrugs designed for improved bioavailability and stability.
• Agrochemical Active Ingredient Synthesis: Serves as a precursor in the manufacturing of advanced herbicides, fungicides, and insecticides, contributing to their specific mode of action.
• Polymer & Material Science: Employed as a monomer or modifying agent to introduce specific functional groups into polymer chains, enhancing material properties.
• Ligand & Catalyst Development: Utilized in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Custom Chemical & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse client projects.

Basic Information

Product Name	3-Benzyloxy-2,2-Dimethylpropionyl Chloride
CAS No.	36881-15-9
Molecular Formula	C₁₂H₁₅ClO₂
Molecular Weight	226.70 g/mol
Synonyms	2,2-Dimethyl-3-(phenylmethoxy)propanoyl Chloride; 3-(Benzyloxy)-2,2-dimethylpropionyl Chloride; 2,2-Dimethyl-3-benzyloxypropionyl Chloride; α,α-Dimethyl-β-benzyloxypropionyl Chloride; NSC 334906; Propanoyl chloride, 3-(phenylmethoxy)-2,2-dimethyl-; Benzyl 2,2-dimethyl-3-chloro-3-oxopropyl ether
EINECS	Contact for details

Quality Control

Every batch of 3-Benzyloxy-2,2-Dimethylpropionyl Chloride is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where required, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.