Description

(S)-(-)-n-(Trifluoroacetyl)Prolyl Chloride is a high-purity, chiral acyl chloride derivative used as a critical chiral derivatizing agent and building block in asymmetric synthesis. Its primary value lies in enabling the resolution and analysis of enantiomers, particularly amino acids and amines, through the formation of stable, separable diastereomers. This compound is essential for research and production in the pharmaceutical industry, where it is used in the development of chiral active pharmaceutical ingredients (APIs), as well as in analytical laboratories for high-precision chiral chromatography.

Application

• Chiral Derivatizing Agent (CDA): For the resolution and analytical determination of enantiomeric purity of amino acids, amines, and alcohols via HPLC, GC, or NMR.
• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of complex, optically active drug molecules and peptides.
• Asymmetric Synthesis: Used in the preparation of chiral auxiliaries and catalysts for stereoselective chemical transformations.
• Analytical Reference Standard: Serves as a high-purity standard for method development and validation in quality control laboratories.
• Proteomics & Biochemistry Research: Employed in the modification and study of peptides and proteins to understand stereochemical interactions.
• Process Development: Utilized in scaling up chiral synthetic routes from laboratory to pilot and commercial manufacturing scales.

Basic Information

Product Name	(S)-(-)-n-(Trifluoroacetyl)Prolyl Chloride
CAS No.	36724-68-2
Molecular Formula	C7H7ClF3NO2
Molecular Weight	229.58 g/mol
Synonyms	(S)-(-)-N-(Trifluoroacetyl)prolyl chloride; L-N-(Trifluoroacetyl)prolyl chloride; (S)-N-Trifluoroacetylprolyl chloride; (S)-1-(Trifluoroacetyl)pyrrolidine-2-carbonyl chloride; (2S)-1-[(Trifluoromethyl)carbonyl]pyrrolidine-2-carbonyl chloride; TFA-Pro-Cl; N-TFA-L-prolyl chloride; Marfey's reagent derivative
EINECS	Contact for details

Quality Control

Our (S)-(-)-n-(Trifluoroacetyl)Prolyl Chloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, assay, and impurity profile. We adhere to relevant industry standards and can support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.