Description

3-Methoxymorphinan Hydrochloride (Nor-De Xtromethorphan) is a key pharmaceutical intermediate and reference standard of significant importance in the research and development of antitussive and neuropharmacological agents. Its primary value lies in its structural relationship to dextromethorphan, making it a critical compound for analytical studies, metabolic pathway investigations, and the synthesis of novel therapeutic candidates. This high-purity chemical is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on central nervous system (CNS) drug discovery and quality control.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of dextromethorphan and related morphinan-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, calibration, and quantification in HPLC, GC-MS, and other analytical techniques for drug purity testing and impurity profiling.
• Metabolic Studies: Serves as a reference compound for investigating the metabolic pathways and pharmacokinetics of dextromethorphan and its analogs.
• Neuropharmacological Research: Employed in preclinical research to study NMDA receptor antagonism and other mechanisms relevant to cough suppression and potential neuroprotective effects.
• Impurity Standard: Used to identify, quantify, and control process-related impurities or degradation products in dextromethorphan API manufacturing.
• Chemical Synthesis: A versatile starting material for medicinal chemists exploring new derivatives with modified pharmacological profiles.

Basic Information

Item	Details
Product Name	3-Methoxymorphinan Hydrochloride (Nor-De Xtromethorphan)
CAS No.	36397-14-5
Molecular Formula	C18H25NO • HCl
Molecular Weight	307.86 g/mol (Free base: 271.40 g/mol)
Synonyms	Nor-Dextromethorphan Hydrochloride; (+)-3-Methoxymorphinan Hydrochloride; (9α,13α,14α)-3-Methoxy-17-methylmorphinan Hydrochloride; Dextrorphan Precursor; 1,2,3,4,5,6,7,8-Octahydro-3-methoxy-11-methyl-2,6-methano-3-benzazocin-9-ol Hydrochloride; Levomethorphan Impurity; Nor-DXM HCl
EINECS	Contact for details

Quality Control

Our 3-Methoxymorphinan Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistent identity, meeting the stringent requirements for pharmaceutical research and development. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from chromatographic purity assays, identification tests, and residual solvent analysis. Our quality commitment supports compliance with cGMP principles where applicable for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.