Description

Dimemorfan Phosphate is a high-purity pharmaceutical intermediate and active ingredient, specifically the phosphate salt form of dimemorfan. This compound is critical for ensuring precise formulation and consistent bioavailability in final drug products. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of antitussive (cough suppressant) medications.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription and over-the-counter cough suppressant syrups, tablets, and lozenges.
• Pharmaceutical Intermediate: Serves as a key synthetic building block in multi-step drug synthesis processes within GMP facilities.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing via HPLC, GC, or spectroscopy.
• Clinical Research Material: Supplied to research organizations and CROs for preclinical studies and clinical trials investigating central nervous system (CNS) activity.
• Formulation Development: Employed in R&D departments for stability testing, excipient compatibility studies, and dosage form optimization.

Basic Information

Product Name	Dimemorfan Phosphate
CAS No.	36304-84-4
Molecular Formula	C18H25N•H3PO4
Molecular Weight	359.39 g/mol
Synonyms	Dimemorfan phosphate; 3,17-Dimethylmorphinan phosphate; ASTOMIN® (as phosphate salt); (+)-3,17-Dimethyl-9α,13α,14α-morphinan phosphate; Dextromethorphan analog phosphate; Dimefrine phosphate (obsolete); 1,2,3,4,5,6,7,8-Octahydro-2-methyl-5-phenylisoquinoline phosphate derivative
EINECS	Contact for details

Quality Control

Our Dimemorfan Phosphate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to ensure regulatory compliance and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.