Description

Amphotericinb CAS NO 36148-89-7 is a potent polyene macrolide antifungal antibiotic derived from *Streptomyces nodosus*. This compound is critically important for its broad-spectrum activity against a wide range of systemic fungal infections. It is an essential active pharmaceutical ingredient (API) primarily required by the pharmaceutical industry for the formulation of injectable antifungal medications. Its efficacy makes it a cornerstone in the treatment of severe, life-threatening mycoses.

Application

• Pharmaceutical API: Primary use as the active ingredient in intravenous and topical antifungal formulations.
• Systemic Antifungal Therapy: Treatment of invasive fungal infections such as aspergillosis, candidiasis, cryptococcal meningitis, and mucormycosis.
• Hospital & Clinical Use: Formulated into liposomal and deoxycholate complexes for enhanced delivery and reduced toxicity in critical care.
• Research & Development: Used as a reference standard in microbiological assays and antifungal drug discovery.
• Veterinary Medicine: Application in treating serious fungal infections in animals.
• Cell Culture & Microbiology: Selective agent in laboratory media to prevent fungal contamination.

Basic Information

Product Name	Amphotericin B
CAS No.	36148-89-7
Molecular Formula	C47H73NO17
Molecular Weight	924.09 g/mol
Synonyms	Amphotericin B; Amphotericin; Amphotericin B, USP; Fungizone; Amphocin; AmB; Anfotericina B; Amphomoronal; Amphozone; Polyene Antifungal Antibiotic; 1397-89-3 (Amphotericin B mixture); 11011-38-4 (Amphotericin B complex)
EINECS	Contact for details

Quality Control

Our Amphotericin B is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent pharmacopeial standards, including USP and EP monographs. Key parameters such as potency, purity, and related substances are verified. A comprehensive Certificate of Analysis (COA) documenting identity, assay, impurities, and microbiological data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), or under refrigeration at 2-8°C (36-46°F) as specified. The product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep the container tightly sealed in a dry, cool, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0% (on dried basis)
Loss on Drying	≤ 5.0 %
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5 %
Related Substances (HPLC)	Total impurities ≤ 5.0% Individual unknown impurity ≤ 1.0%
Microbial Enumeration	Meets USP/EP criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.