Description

2-Phenyl-1,3-thiazole-4-carbonyl chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 2-phenylthiazole-4-carbonyl moiety, a privileged scaffold in medicinal chemistry, into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, especially those targeting various enzymes and receptors where the thiazole core is pharmacologically active.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Peptide Mimetics & Conjugation: Employed to create thiazole-containing peptide analogs or for conjugating the thiazole moiety to biomolecules via amide bond formation.
• Material Science Research: Serves as a precursor for functionalized polymers or organic electronic materials that incorporate heterocyclic units.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or affinity labels to study biological processes.
• Custom Synthesis & Contract Manufacturing: A high-value reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Phenyl-1,3-thiazole-4-carbonyl chloride
CAS No.	36094-04-9
Molecular Formula	C10H6ClNOS
Molecular Weight	223.68 g/mol
Synonyms	4-Thiazolecarbonyl chloride, 2-phenyl-; 2-Phenyl-4-thiazolecarbonyl chloride; 2-Phenylthiazole-4-carbonyl chloride; 2-Phenyl-δ⁴-thiazoline-4-carbonyl chloride; (2-Phenyl-1,3-thiazol-4-yl)carbonyl chloride; 36094-04-9; 2-Phenyl-1,3-thiazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 2-Phenyl-1,3-thiazole-4-carbonyl chloride is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.