Description

Cyclopropanecarboxylic Acid, 2-(Chlorocarbonyl)-, Methyl Ester, (1R,2R)-Rel- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its core value lies in its functionalized cyclopropane ring and activated ester group, which enable the efficient construction of complex, biologically active molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with precise three-dimensional structures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors, receptor modulators, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the strained cyclopropane ring can impart unique biological activity and stability.
• Advanced Material Precursor: Serves as a building block for specialty polymers and liquid crystals that require specific stereochemistry for optimal performance.
• Chemical Biology & Probe Development: Employed in the creation of activity-based probes and molecular tools for studying enzyme function and biological pathways.
• Asymmetric Catalysis Research: Utilized as a substrate or ligand precursor in the development and testing of new chiral catalysts.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector with complex, multi-step synthetic sequences.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-(Chlorocarbonyl)-, Methyl Ester, (1R,2R)-Rel- (9Ci)
CAS No.	35974-58-4
Molecular Formula	C6H7ClO3
Molecular Weight	162.57 g/mol
Synonyms	(1R,2R)-Methyl 2-(chlorocarbonyl)cyclopropanecarboxylate; (1R,2R)-rel-2-(Chlorocarbonyl)cyclopropanecarboxylic Acid Methyl Ester; Methyl (1R,2R)-2-(chloroformyl)cyclopropane-1-carboxylate; trans-Methyl 2-(chlorocarbonyl)cyclopropanecarboxylate; (1R,2R)-Cyclopropane-1,2-dicarboxylic Acid 1-Methyl Ester 2-Chloride; 35974-58-4; (1R,2R)-Methyl 2-(chloroformyl)cyclopropanecarboxylate
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, which is critical for sensitive synthetic applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.