Description

5'-Amino-2',5'-Dideoxyuridine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial building block for the synthesis of novel antiviral and anticancer agents, particularly in the development of nucleoside reverse transcriptase inhibitors. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the discovery of new therapeutic entities targeting viral infections and oncology. The compound's unique structure, featuring a 5'-amino group, allows for targeted chemical modifications to enhance biological activity and selectivity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral drugs, including potential treatments for HIV and hepatitis.
• Anticancer Agent Research: Used as a scaffold for developing prodrugs and targeted therapies that interfere with DNA synthesis in cancer cells.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate the mechanisms of nucleoside-metabolizing enzymes.
• Probe Development: Utilized in the creation of molecular probes for studying cellular uptake and intracellular trafficking of nucleosides.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies to optimize drug potency and reduce toxicity.

Basic Information

Product Name	5'-Amino-2',5'-Dideoxyuridine
CAS No.	35959-38-7
Molecular Formula	C9H13N3O5
Molecular Weight	243.22 g/mol
Synonyms	5'-Amino-2',5'-dideoxyuridine; 2',5'-Dideoxy-5'-aminouridine; 5'-Amino-2',5'-dideoxy-Uridine; 5'-Amino-ddU; 5'-NH2-ddU; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-amino-1,2,3,4-tetrahydropyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5'-Amino-2',5'-Dideoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.