Description

5'-Azido-2',5'-Dideoxyuridine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and life science research. Its unique azido functional group makes it a versatile intermediate for click chemistry applications, enabling the synthesis of complex biomolecular probes and potential therapeutic agents. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who are developing novel antiviral agents, nucleotide-based prodrugs, and targeted molecular conjugates.

Application

• Medicinal Chemistry Intermediate: A crucial precursor for the synthesis of novel nucleoside analogs with potential antiviral or anticancer activity.
• Click Chemistry Reagent: The azido group enables efficient, bioorthogonal Huisgen cycloaddition (copper-catalyzed azide-alkyne cycloaddition) for labeling and bioconjugation.
• Biomolecular Probe Development: Used to create labeled nucleotides for studying DNA/RNA metabolism, enzyme mechanisms, and cellular processes.
• Prodrug Synthesis: Serves as a building block for designing masked nucleotide prodrugs aimed at improving bioavailability and targeted delivery.
• Antiviral Research: Investigated as a scaffold for developing inhibitors of viral polymerases, particularly in herpesvirus and retrovirus research.
• Diagnostic Assay Components: Incorporated into the development of diagnostic kits and assays that utilize nucleotide-based detection systems.

Basic Information

Product Name	5'-Azido-2',5'-Dideoxyuridine
CAS No.	35959-37-6
Molecular Formula	C9H11N5O5
Molecular Weight	269.22 g/mol
Synonyms	5'-Azido-2',5'-dideoxyuridine; 2',5'-Dideoxy-5'-azidouridine; 1-[(2R,5S)-5-Azido-5-deoxy-2-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione; 5'-N3-2',5'-ddU; Azidodideoxyuridine; 5'-Azido-ddU; 5'-Azido-2',5'-dideoxy-Urd
EINECS	Contact for details

Quality Control

Our 5'-Azido-2',5'-Dideoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.