Description

5'-Deoxy-5'-[3,4-Dihydro-5-Methyl-2,4-Dioxopyrimidin-1(2H)-Yl]Thymidine is a sophisticated nucleoside analogue of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation nucleoside-based therapies.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and production of novel antiviral and anticancer nucleoside analogues.
• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Antiviral Drug Development: Serves as a core structural component for designing compounds targeting viral polymerases and reverse transcriptases.
• Oncology Research: Investigated for its potential incorporation into prodrugs or as a modulator of cellular nucleotide pools in cancer cell lines.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.
• Reference Standard: Employed as an analytical standard in quality control and method development for related pharmaceutical products.

Basic Information

Product Name	5'-Deoxy-5'-[3,4-Dihydro-5-Methyl-2,4-Dioxopyrimidin-1(2H)-Yl]Thymidine
CAS No.	35959-35-4
Molecular Formula	C15H19N3O6
Molecular Weight	337.33 g/mol
Synonyms	5'-Deoxy-5'-(3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)thymidine; 1-(5-Deoxy-β-D-threo-pent-4-enofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-Deoxy-5'-(dihydrothymin-1-yl)thymidine; NSC 356687; 5'-Deoxy-5'-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)thymidine; Dihydrothymidine Dimer; Thymidine Dihydrothymidine Dimer
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5'-[3,4-Dihydro-5-Methyl-2,4-Dioxopyrimidin-1(2H)-Yl]Thymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the exacting standards of pharmaceutical R&D, and specifications can be aligned with client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.