Description

Neca CAS NO 35920-39-9 is a potent and selective adenosine A1 receptor agonist, a key compound in neurological and cardiovascular research. Its high specificity makes it an invaluable pharmacological tool for studying receptor signaling pathways and developing therapeutic agents. This product is essential for research institutions and pharmaceutical companies focused on drug discovery for conditions like cardiac arrhythmias, neuropathic pain, and renal disorders.

Application

• Neurological Research: Used as a standard agonist to investigate the role of adenosine A1 receptors in the central nervous system, including studies on neuroprotection, sedation, and anticonvulsant effects.
• Cardiovascular Pharmacology: Employed in preclinical research to study heart rate regulation, myocardial ischemia, and the cardioprotective effects mediated by A1 receptor activation.
• Renal Function Studies: Applied in research exploring adenosine's role in regulating renal blood flow, glomerular filtration rate, and tubuloglomerular feedback mechanisms.
• Analgesic Research: Utilized in models to evaluate the potential of A1 receptor agonists for managing neuropathic and inflammatory pain.
• Biochemical Assay Development: Serves as a reference standard in high-throughput screening (HTS) and radioligand binding assays to identify and characterize new A1 receptor ligands.
• Academic & Institutional Research: A fundamental tool for universities and research institutes conducting basic science on purinergic signaling and receptor pharmacology.

Basic Information

Product Name	Neca
CAS No.	35920-39-9
Molecular Formula	C13H18N6O4
Molecular Weight	322.32 g/mol
Synonyms	5'-N-ethylcarboxamidoadenosine; NECA; 1-[6-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-2-yl]-N-ethylpyrazole-4-carboxamide; Adenosine, N-ethyl-5'-carboxamide; A1 adenosine receptor agonist NECA; Ethyl[1-(6-amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronosyl]carbamate
EINECS	Contact for details

Quality Control

Our Neca CAS NO 35920-39-9 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS), to ensure consistency and reliability for critical research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.