Description

5-Aminoimidazole-4-Carboxamide-1-B-D-ribofuranoside (AICAR) is a crucial nucleoside analog and a key intermediate in the biosynthesis of purine nucleotides. This compound matters significantly as a potent activator of AMP-activated protein kinase (AMPK), making it a vital research tool for studying cellular energy homeostasis, metabolic pathways, and potential therapeutic applications. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors for drug discovery and biochemical studies.

Application

• Pharmaceutical Research & Intermediate: Serves as a critical building block and reference standard in the synthesis and development of novel nucleoside-based therapeutics.
• Biochemical Research: Widely used as a specific AMPK activator to investigate metabolic disorders, diabetes, cardiac ischemia, and exercise physiology in cellular and animal models.
• Metabolic Pathway Studies: Essential for probing the AMPK signaling pathway, which regulates glucose and lipid metabolism, mitochondrial biogenesis, and cell growth.
• Academic & Institutional Research: Employed in universities and research institutes for fundamental studies in biochemistry, molecular biology, and physiology.
• Preclinical Development: Used in early-stage drug discovery to validate targets related to energy metabolism and assess the efficacy of related compounds.

Basic Information

Product Name	5-Aminoimidazole-4-Carboxamide-1-B-D-ribofuranoside
CAS No.	35908-14-6
Molecular Formula	C9H14N4O5
Molecular Weight	258.23 g/mol
Synonyms	AICAR; Acadesine; 5-Amino-1-β-D-ribofuranosylimidazole-4-carboxamide; 5-Aminoimidazole-4-carboxamide ribonucleoside; 5-Amino-4-imidazolecarboxamide riboside; AICA ribonucleoside; Z-Riboside
EINECS	Contact for details

Quality Control

Our 5-Aminoimidazole-4-Carboxamide-1-B-D-ribofuranoside is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity standards suitable for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.