Description

5'-Isobutylthio-5'-Deoxyadenosine is a chemically modified nucleoside derivative, serving as a critical intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside-based medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside analog prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Research: Used in the development of potential antiviral agents targeting viral polymerases and replication mechanisms.
• Oncology Drug Discovery: Serves as a precursor in the creation of chemotherapeutic compounds designed to interfere with cancer cell DNA/RNA synthesis.
• Biochemical Tool Compound: Employed in enzymatic studies and as a substrate analog to investigate the function of nucleoside-processing enzymes.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to optimize the pharmacokinetic and pharmacodynamic properties of lead compounds.
• Pre-clinical Development: Supplies material for in vitro and in vivo efficacy and toxicity studies during the drug candidate selection phase.

Basic Information

Product Name	5'-Isobutylthio-5'-Deoxyadenosine
CAS No.	35899-54-8
Molecular Formula	C₁₄H₂₁N₅O₃S
Molecular Weight	339.42 g/mol
Synonyms	5'-(2-Methylpropylthio)-5'-deoxyadenosine; 5'-Deoxy-5'-(isobutylthio)adenosine; 9-[(5-S-Butyl-5-thio-β-D-ribofuranosyl)purine]; 5'-S-Isobutyl-5'-thioadenosine; Isobutylthioadenosine; 5'-Deoxy-5'-(2-methylpropylthio)adenosine; Adenosine, 5'-deoxy-5'-(isobutylthio)-
EINECS	Contact for details

Quality Control

Our 5'-Isobutylthio-5'-Deoxyadenosine is produced under a strict quality management system to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.