Description

8-Aminoadenosine Triphosphate is a chemically modified nucleotide analog of adenosine triphosphate (ATP) where the 8-position of the adenine ring is substituted with an amino group. This structural modification makes it a valuable biochemical tool for studying enzyme kinetics, nucleotide-binding proteins, and signal transduction pathways. It is primarily utilized by researchers and manufacturers in the fields of biochemistry, molecular biology, and pharmaceutical development for probing ATP-dependent processes and developing novel assays.

Application

• Enzyme Substrate & Inhibition Studies: Used as a substrate analog to investigate the mechanism and specificity of kinases, ATPases, and other ATP-binding enzymes.
• Biochemical Assay Development: Serves as a key component in high-throughput screening (HTS) assays for drug discovery targeting nucleotide-binding sites.
• Structural Biology Research: Employed in X-ray crystallography and NMR studies to elucidate protein-ligand interaction structures.
• Signal Transduction Research: Applied in studies of purinergic signaling pathways and G-protein coupled receptors (GPCRs).
• Diagnostic Reagent Manufacturing: Incorporated into diagnostic kits for monitoring enzymatic activities relevant to clinical biomarkers.
• Nucleic Acid Research: Potential use in studying RNA metabolism and processing enzymes that utilize ATP analogs.

Basic Information

Product Name	8-Aminoadenosine Triphosphate
CAS No.	35874-49-8
Molecular Formula	C10H17N6O13P3
Molecular Weight	546.18 g/mol
Synonyms	8-Amino-ATP; 8-NH2-ATP; Adenosine 5'-(tetrahydrogen triphosphate), 8-amino-; 8-Aminoadenosine 5'-triphosphate; 8-Amino-5'-ATP; ATP, 8-amino-; 8-Amino adenosine triphosphate
EINECS	Contact for details

Quality Control

Our 8-Aminoadenosine Triphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) documenting purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0 %
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.