Description

1-(Trimethylsilyl)-4-Fluoronaphthalene is a specialized organosilicon building block that combines a fluorinated naphthalene core with a reactive trimethylsilyl group. This compound is valued for its dual functionality, serving as a key intermediate in advanced organic synthesis, particularly in the development of complex molecules for material science and pharmaceuticals. It is primarily sought by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and advanced materials sectors for constructing novel fluorinated aromatic systems.

Application

• Pharmaceutical Intermediate: Used in the synthesis of fluorinated drug candidates, leveraging the fluorine atom for metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for novel pesticides and herbicides where the fluoronaphthalene moiety imparts specific biological activity.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and fluorinated polymers for electronic applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) where the trimethylsilyl group can be transformed or used as a directing/protecting group.
• Fluorine Chemistry Studies: A valuable reagent for investigating structure-activity relationships (SAR) and new fluorination methodologies.
• Ligand and Catalyst Development: Used to create sophisticated fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-(Trimethylsilyl)-4-Fluoronaphthalene
CAS No.	35869-77-3
Molecular Formula	C₁₃H₁₅FSi
Molecular Weight	218.34 g/mol
Synonyms	4-Fluoro-1-(trimethylsilyl)naphthalene; 1-(Trimethylsilyl)-4-fluoronaphthalene; 4-Fluoro-1-naphthyltrimethylsilane; Naphthalene, 1-(trimethylsilyl)-4-fluoro-; Trimethyl(4-fluoronaphthalen-1-yl)silane
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-4-Fluoronaphthalene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.