Description

2'-O,3'-o-Benzylideneuridine 5'-(4-Methylbenzene-1-Sulfonate) is a key nucleoside derivative, specifically a protected uridine intermediate, where the 2' and 3' hydroxyl groups are blocked by a benzylidene acetal. This compound is critical for synthetic chemists as it enables the selective functionalization of the 5'-hydroxyl group, a pivotal step in the synthesis of modified oligonucleotides and nucleoside analogs. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of antiviral agents, mRNA therapeutics, and other nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA sequences for research and therapeutic applications, including antisense oligonucleotides and siRNA.
• Prodrug Development: Serves as a precursor for creating prodrugs of nucleoside analogs to enhance bioavailability and targeting.
• Biochemical Research: Employed in studies of enzyme mechanisms, nucleic acid chemistry, and as a tool compound in molecular biology.
• Labeled Compound Synthesis: Acts as a starting material for the synthesis of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and NMR studies.
• Chemical Biology Probes: Used to create affinity probes or cross-linkers for studying nucleic acid-protein interactions.

Basic Information

Product Name	2'-O,3'-o-Benzylideneuridine 5'-(4-Methylbenzene-1-Sulfonate)
CAS No.	35837-30-0
Molecular Formula	C23H22N2O9S
Molecular Weight	502.49 g/mol
Synonyms	Uridine, 2,3-O-(phenylmethylene)-, 5'-(4-methylbenzenesulfonate); 2',3'-O-Benzylideneuridine 5'-Tosylate; 2',3'-O-Benzylidene-5'-O-tosyluridine; 5'-O-Tosyl-2',3'-O-benzylideneuridine; 2',3'-O-(Phenylmethylene)uridine 5'-(p-toluenesulfonate); 2',3'-O-Benzylidene-5'-O-(p-toluenesulfonyl)uridine; Uridine, 2,3-O-benzylidene-, 5'-(p-toluenesulfonate)
EINECS	Contact for details

Quality Control

Our 2'-O,3'-o-Benzylideneuridine 5'-(4-Methylbenzene-1-Sulfonate) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles (typically by HPLC, NMR) is provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.