Description

2-Thiouridine5'-Triphosphatetetrasodiumsalt is a chemically modified nucleotide triphosphate analog, specifically a sodium salt of 2-thiouridine triphosphate. This compound is critical for biochemical research and development, offering a sulfur-substituted uracil base that can alter base-pairing properties and stability. It is primarily utilized by research scientists and process developers in the fields of molecular biology, enzymology, and nucleic acid chemistry for applications such as probe synthesis and mechanistic studies.

Application

• Nucleic Acid Research: Used as a modified substrate for studying RNA polymerase and reverse transcriptase activity and fidelity.
• Probe Synthesis: Incorporation into oligonucleotides to create labeled probes for hybridization assays, leveraging potential altered fluorescence or binding characteristics.
• Enzymology Studies: Serves as a tool to investigate the substrate specificity and catalytic mechanisms of kinases, polymerases, and other nucleotide-processing enzymes.
• Structural Biology: Can be used to prepare modified RNA for X-ray crystallography or NMR studies to understand the impact of thiolation on nucleic acid structure.
• Antiviral & Therapeutic Research: Potential building block in the development of nucleotide analogs for screening against viral polymerases.
• Diagnostic Assay Development: May be employed in the design of novel diagnostic primers or probes that require specific thermal or binding properties.

Basic Information

Product Name	2-Thiouridine5'-Triphosphatetetrasodiumsalt
CAS No.	35763-29-2
Molecular Formula	C9H11N2O14P3S · 4Na
Molecular Weight	Approx. 670.1 g/mol (Contact for exact details)
Synonyms	2-Thio-UTP tetrasodium salt; 2-Thiouridine-5'-triphosphate tetrasodium salt; s2UTP Na4; UTP-2-thiol tetrasodium; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(6-hydroxy-2-mercapto-4-oxopyrimidin-1(4H)-yl)tetrahydrofuran-2-yl) 5-(trihydrogen triphosphate) tetrasodium salt; 2-Thio-uridine-5'-(tetrahydrogen triphosphate) tetrasodium salt
EINECS	Contact for details

Quality Control

Our 2-Thiouridine5'-Triphosphatetetrasodiumsalt is produced under a quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR identification, and endotoxin levels are available upon request to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5%
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.