Description

p-Tolyl-Acetyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, essential for introducing the p-tolylacetyl moiety into target molecules. Its primary value lies in its role as a key acylating and coupling agent in the synthesis of complex organic compounds, enabling the formation of amides, esters, and ketones. This intermediate is critically needed by R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries for developing active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of novel amide and ester-based drugs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and pesticides, where it acts as an acylating agent to create bioactive molecules.
• Peptide & Polymer Chemistry: Serves as a coupling reagent and monomer derivative in the synthesis of specialty polymers and modified peptides.
• Dye & Pigment Manufacturing: Employed in the synthesis of complex organic dyes and colorants, contributing to chromophore development.
• Liquid Crystal & OLED Material Production: A crucial intermediate for creating advanced organic electronic materials and liquid crystal compounds.
• Organic Synthesis & Research: A fundamental reagent in academic and industrial laboratories for constructing complex molecular architectures through Friedel-Crafts acylation and nucleophilic substitution reactions.

Basic Information

Product Name	p-Tolyl-Acetyl Chloride
CAS No.	35675-44-6
Molecular Formula	C9H9ClO
Molecular Weight	168.62 g/mol
Synonyms	4-Methylphenylacetyl Chloride; p-Methylphenylacetyl Chloride; (4-Methylphenyl)acetyl Chloride; 2-(4-Methylphenyl)acetyl Chloride; 4-Tolylacetyl Chloride; p-Tolylacetic Acid Chloride; α-(p-Tolyl)acetyl Chloride; 4-Methylbenzeneacetyl Chloride
EINECS	Contact for details

Quality Control

Our p-Tolyl-Acetyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts violently with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and ensure maximum shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.