Description

2'-Deoxy-N6,N6-Dimethyladenosine is a chemically modified nucleoside analog, a key building block in advanced biochemical research and pharmaceutical development. This compound matters for its role as a crucial intermediate in the synthesis of modified oligonucleotides and potential therapeutic agents, offering researchers precise control over molecular structure and function. It is primarily needed by biotechnology firms, pharmaceutical R&D laboratories, and academic institutions focused on nucleic acid chemistry, antiviral research, and the development of novel diagnostic tools.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for introducing dimethyladenosine modifications into synthetic DNA strands for research and diagnostics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and related pathways.
• Antiviral Drug Development: Serves as a core scaffold or intermediate in the research and synthesis of nucleoside analog prodrugs targeting viral polymerases.
• Structural Biology Studies: Incorporated into nucleic acid sequences to study the effects of base methylation on duplex stability, protein binding, and conformational dynamics.
• Diagnostic Probe Design: Utilized to create labeled probes with tailored binding properties for advanced molecular detection assays.
• Academic & Industrial R&D: A fundamental reagent for exploring novel chemical entities in medicinal chemistry and life science research programs.

Basic Information

Product Name	2'-Deoxy-N6,N6-Dimethyladenosine
CAS No.	35665-58-8
Molecular Formula	C12H17N5O3
Molecular Weight	279.30 g/mol
Synonyms	N6,N6-Dimethyl-2'-deoxyadenosine; 2'-Deoxy-N6,N6-dimethyladenosine; 6-(Dimethylamino)-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine; 6-Dimethylaminopurine 2'-deoxyriboside; dDMA; 2'-dDMA; N6,N6-Dimethyl-deoxyadenosine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-N6,N6-Dimethyladenosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.