Description

2,5-Difluorobenzoylchloride CAS NO 35370-09-7 is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the 2,5-difluorobenzoyl moiety, a key structural feature for modulating the physical, chemical, and biological properties of target molecules. This high-purity intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoro substitution pattern enhances bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores essential in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer chains, improving material properties like chemical resistance, thermal stability, and surface characteristics.
• Peptide & Protein Research: Acts as an acylating agent for modifying amino acids or peptides, useful in biochemical research and probe development.
• Dye & Pigment Manufacturing: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer unique color fastness and spectral properties.

Basic Information

Product Name	2,5-Difluorobenzoylchloride
CAS No.	35370-09-7
Molecular Formula	C7H3ClF2O
Molecular Weight	176.55 g/mol
Synonyms	2,5-Difluorobenzoyl Chloride; Benzoyl chloride, 2,5-difluoro-; 2,5-Difluorobenzoic acid chloride; α,2,5-Trifluorotoluene; 2,5-Difluorobenzoylchloride; 35370-09-7; 2,5-Difluorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our 2,5-Difluorobenzoylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, impurity profile, and physical properties is provided with every shipment to guarantee compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C. This compound is hygroscopic (moisture-sensitive) and reacts with water, strong bases, and alcohols. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.