Description

(R)-2-Azido-2-Phenylacetyl Chloride is a chiral, highly reactive acid chloride derivative, serving as a critical building block in asymmetric synthesis. Its value lies in enabling the efficient introduction of the (R)-2-azido-2-phenylacetyl moiety, a versatile precursor to unnatural amino acids and other pharmacologically active chiral compounds. This product is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly those developing peptide mimetics, enzyme inhibitors, and novel active pharmaceutical ingredients (APIs).

Application

• Chiral Intermediate in Pharmaceutical Synthesis: Key precursor for the production of (R)-α-azido phenylacetic acid and its derivatives, which are valuable in constructing peptidomimetics and enzyme inhibitors.
• Asymmetric Synthesis of Unnatural Amino Acids: Used to incorporate chiral, azide-functionalized side chains into peptide backbones for drug discovery and biochemical research.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Bioconjugation and Click Chemistry: The azide group allows for subsequent copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling labeling and conjugation in chemical biology.
• Agrochemical Research: Employed in the synthesis of chiral active ingredients for crop protection products.
• Academic and R&D Laboratories: Fundamental reagent for methodological development in organic and medicinal chemistry focused on stereocontrol.

Basic Information

Product Name	(R)-2-Azido-2-Phenylacetyl Chloride
CAS No.	35353-41-4
Molecular Formula	C8H6ClN3O
Molecular Weight	195.61 g/mol
Synonyms	(R)-α-Azidophenylacetyl chloride; (R)-2-Azido-2-phenylacetyl chloride; (R)-Azidophenylacetic acid chloride; (R)-N3Phe-Cl; (R)-2-Azido-2-phenylethanoyl chloride; (R)-APAC; (2R)-2-Azido-2-phenylacetyl chloride
EINECS	Contact for details

Quality Control

Our (R)-2-Azido-2-Phenylacetyl Chloride is manufactured under strict quality protocols to ensure high chiral purity and chemical integrity, suitable for demanding synthetic applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as enantiomeric excess (ee), chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its moisture-sensitive and strong acid/organic solvent nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and decomposition. Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.