Description

3'-O,5'-o-Bis(Trifluoroacetyl)-2'-Deoxy-n-Methyl-n-(Trifluoroacetyl)Adenosine is a sophisticated, multi-protected nucleoside derivative, specifically engineered for advanced synthetic chemistry. This compound is a critical high-purity intermediate for the synthesis of modified oligonucleotides and nucleotide analogs, offering precise control over molecular structure. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in nucleic acid therapeutics, antiviral agents, and molecular probes.

Application

• Key Intermediate in Oligonucleotide Synthesis: Serves as a protected building block for the solid-phase or solution-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Antiviral Drug Research: Used in the development and study of nucleoside-based prodrugs and antiviral compounds targeting viral polymerases.
• Biochemical Tool Development: Employed in creating labeled or modified nucleotides for use as probes in genomics and molecular biology research.
• Medicinal Chemistry & SAR Studies: Facilitates structure-activity relationship studies by allowing specific modifications to the adenosine scaffold.
• Precursor for Specialty Chemicals: Acts as a starting material for the synthesis of more complex, high-value nucleotide derivatives and catalysts.

Basic Information

Product Name	3'-O,5'-o-Bis(Trifluoroacetyl)-2'-Deoxy-n-Methyl-n-(Trifluoroacetyl)Adenosine
CAS No.	35170-12-8
Molecular Formula	C17H15F9N5O6
Molecular Weight	589.23 g/mol
Synonyms	N6-Methyl-2'-deoxy-N6-(trifluoroacetyl)adenosine 3',5'-bis(trifluoroacetate); 2'-Deoxy-N6-methyl-N6-(trifluoroacetyl)adenosine 3',5'-bis(trifluoroacetate); 3',5'-Di-O-trifluoroacetyl-2'-deoxy-N6-methyl-N6-(trifluoroacetyl)adenosine; N6-Methyl-2'-deoxyadenosine N6,3',5'-tris(trifluoroacetate); Protected 2'-Deoxy-N6-methyladenosine Derivative; 35170-12-8 (CAS Index Name)
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for sensitive research and synthesis. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. Our quality system is designed to support GMP-grade applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.