Description

3'-O,5'-o-Bis(Trifluoroacetyl)-2'-Deoxy-n-(Trifluoroacetyl)Guanosine is a key trifluoroacetyl-protected derivative of 2'-deoxyguanosine, essential for advanced oligonucleotide synthesis. This high-purity intermediate is critical for researchers and manufacturers requiring precise control over nucleoside chemistry to prevent unwanted side reactions. It is primarily utilized in the development and production of therapeutic oligonucleotides, including antisense drugs and siRNA, as well as in diagnostic probe synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block in the solid-phase synthesis of therapeutic oligonucleotides, such as antisense oligonucleotides (ASOs) and small interfering RNA (siRNA).
• Research & Development: Used in academic and industrial labs for studying nucleic acid chemistry, modifying oligonucleotide backbones, and developing novel nucleotide analogs.
• Diagnostic Probe Synthesis: Employed in the manufacture of labeled probes and primers for genetic testing, PCR, and other molecular diagnostic applications.
• Process Development: Serves as a standard or reference material for scaling up GMP-compliant manufacturing processes for nucleic acid-based therapeutics.

Basic Information

Product Name	3'-O,5'-o-Bis(Trifluoroacetyl)-2'-Deoxy-n-(Trifluoroacetyl)Guanosine
CAS No.	35170-11-7
Molecular Formula	C₁₉H₁₆F₉N₅O₇
Molecular Weight	621.34 g/mol
Synonyms	2'-Deoxy-N2,3',5'-tris(trifluoroacetyl)guanosine; N2,3',5'-Tris(trifluoroacetyl)-2'-deoxyguanosine; 2'-Deoxyguanosine, N2,3',5'-tris(2,2,2-trifluoroacetate); 2'-Deoxyguanosine tris(trifluoroacetate) derivative; dG-TFA derivative; Protected 2'-deoxyguanosine; Guanosine, 2'-deoxy-, N2,3',5'-tris(trifluoroacetate)
EINECS	Contact for details

Quality Control

Our 3'-O,5'-o-Bis(Trifluoroacetyl)-2'-Deoxy-n-(Trifluoroacetyl)Guanosine is manufactured under strict quality systems to ensure batch-to-batch consistency suitable for research and pharmaceutical applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and solvent residues is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to decomposition. For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.