Description

Cyclobutanecarbonyl Chloride, 1-(Methylthio)- (9Ci) is a specialized organosulfur building block featuring a reactive acid chloride group and a methylthio substituent on a cyclobutane ring. This unique structure makes it a valuable intermediate for synthesizing complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, where its scaffold provides a key structural motif. The compound is commercially available under CAS number 35120-21-9.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting cyclobutane-containing bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where the methylthio and carbonyl chloride functionalities allow for further derivatization.
• Advanced Material Precursor: Serves as a monomer or cross-linking agent in the development of specialized polymers and functional materials with unique thermal or mechanical properties.
• Chemical Biology Probes: Employed in the creation of activity-based probes or affinity labels for studying enzyme function and protein interactions.
• Ligand and Catalyst Development: Useful for constructing novel ligands for transition metal catalysis or organocatalysts in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific high-value intermediate.

Basic Information

Product Name	Cyclobutanecarbonyl Chloride, 1-(Methylthio)- (9Ci)
CAS No.	35120-21-9
Molecular Formula	C6H9ClOS
Molecular Weight	164.65 g/mol
Synonyms	1-(Methylthio)cyclobutanecarbonyl chloride; 1-Methylsulfanylcyclobutanecarbonyl chloride; Cyclobutanecarbonyl chloride, 1-(methylthio)-; 1-(Methylmercapto)cyclobutanecarboxylic acid chloride; 1-(Methylsulfanyl)cyclobutanecarboxylic acid chloride; 35120-21-9; 1-Methylthiocyclobutanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our Cyclobutanecarbonyl Chloride, 1-(Methylthio)- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical quality attributes are provided with every shipment. We support cGMP-compliant manufacturing for advanced pharmaceutical applications, ensuring full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.