Description

2-Thiodeoxyuridine is a modified nucleoside analog where the oxygen atom at the 2' position of the deoxyribose sugar is replaced by a sulfur atom. This structural modification is significant for its role as a biochemical tool in studying nucleic acid metabolism and enzyme mechanisms. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral and anticancer research, as well as in the development of novel diagnostic probes.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for thymidine kinase and other nucleoside-metabolizing enzymes.
• Antiviral Drug Development: Investigated for its potential incorporation into viral DNA/RNA, acting as a chain terminator or mutagen in research settings.
• Oncology Research: Studied for its cytotoxic effects and potential to sensitize cancer cells to radiation or other chemotherapeutic agents.
• Molecular Biology: Serves as a building block for the synthesis of oligonucleotide probes to study DNA/RNA structure and function.
• Diagnostic Agent Synthesis: A key intermediate in the development of labeled compounds for imaging and diagnostic assays.
• Reference Standard: Employed as a high-purity analytical standard in pharmaceutical quality control and method validation.

Basic Information

Item	Detail
Product Name	2-Thiodeoxyuridine
CAS No.	35059-12-2
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	2'-Deoxy-2-thiouridine; 2-Thio-2'-deoxyuridine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-1,2-dihydropyrimidin-4-one; 2-Thiothymidine (common misnomer); d2SU; 2-S-2'-dUrd; 2-Thio-dU
EINECS	Contact for details

Quality Control

Our 2-Thiodeoxyuridine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.