Description

2',5'-Dichloro-2',5'-Dideoxyuridine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical building block and intermediate for the synthesis of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in nucleoside chemistry. The product is supplied with a focus on high purity and batch-to-batch consistency to support advanced synthetic applications.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and related pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Antiviral Agent Development: Investigated for its potential activity against DNA viruses due to its modified sugar moiety.
• Labeled Compound Synthesis: Starting material for the preparation of isotopically labeled (e.g., C-13, N-15) compounds for metabolic tracing studies.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic synthesis and chemical biology.

Basic Information

Product Name	2',5'-Dichloro-2',5'-Dideoxyuridine
CAS No.	34627-73-1
Molecular Formula	C9H10Cl2N2O5
Molecular Weight	297.09 g/mol
Synonyms	2',5'-Dichloro-2',5'-dideoxyuridine; 5-(2,5-Dichloro-2,5-dideoxy-β-D-ribofuranosyl)uracil; 1-[(2R,3S,5R)-3,5-Dichloro-2-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione; NSC 38296; 2',5'-Dichloro-2',5'-dideoxy-uridine; DCDDU
EINECS	Contact for details

Quality Control

Our 2',5'-Dichloro-2',5'-Dideoxyuridine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and synthesis. Each batch is characterized by techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.