Description

3'-Chloro-3'-Deoxy-5'-o-Tritylthymidine is a key nucleoside derivative and a vital synthetic intermediate in organic chemistry. This compound is essential for researchers and manufacturers developing novel pharmaceuticals, particularly in the field of antiviral and anticancer nucleoside analogs. It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical synthesis industries for advanced research and process development.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of modified nucleoside analogs for antiviral and anticancer drug discovery.
• Antisense Oligonucleotide Research: Used in the development of modified oligonucleotides for therapeutic and diagnostic applications.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to DNA metabolism and repair.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Pro-drug Synthesis: A precursor for creating more bioavailable or targeted forms of therapeutic nucleosides.
• Academic Research: Used in universities and research institutes for studying nucleic acid chemistry and medicinal chemistry.

Basic Information

Product Name	3'-Chloro-3'-Deoxy-5'-o-Tritylthymidine
CAS No.	34627-62-8
Molecular Formula	C29H27ClN2O5
Molecular Weight	519.00 g/mol
Synonyms	5'-O-Trityl-3'-chloro-3'-deoxythymidine; 3'-Chloro-3'-deoxy-5'-O-tritylthymidine; 3'-Chloro-5'-O-tritylthymidine; 1-[(2R,5S)-5-Chloro-2-[[triphenylmethyl]oxy]methyl]oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione; Thymidine, 3'-chloro-3'-deoxy-5'-O-trityl-; 3'-Chloro-3'-deoxy-5'-O-(triphenylmethyl)thymidine
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3'-Deoxy-5'-o-Tritylthymidine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a desiccated environment away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.