Description

(S)-(+)-Mepivacaine Monohydrochloride CAS NO 34333-71-6 is the pharmacologically active enantiomer of the local anesthetic mepivacaine, presented as its stable monohydrochloride salt. This high-purity chiral intermediate is critical for the development of enantiomerically pure pharmaceutical formulations, offering superior specificity and reduced side-effect profiles compared to racemic mixtures. It is primarily required by pharmaceutical R&D laboratories, advanced fine chemical manufacturers, and producers of specialized anesthetic and analgesic APIs targeting the central nervous system.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: As a key chiral building block for the production of single-enantiomer local anesthetics.
• Neurological Research: Used in preclinical studies to investigate sodium channel blockade and nerve signal transmission mechanisms.
• Analgesic Formulation Development: Serves as a reference standard and active component in developing new pain management solutions.
• Dental and Regional Anesthesia: A critical intermediate for manufacturing the pure (S)-enantiomer used in injectable anesthetic preparations.
• Chiral Catalyst and Ligand Studies: Employed in asymmetric synthesis research due to its defined stereochemistry.
• Quality Control & Analytical Standards: Used as a high-purity certified reference material (CRM) for HPLC, GC, and spectroscopic method development.

Basic Information

Product Name	(S)-(+)-Mepivacaine Monohydrochloride
CAS No.	34333-71-6
Molecular Formula	C15H23ClN2O • HCl
Molecular Weight	311.27 g/mol (as monohydrochloride)
Synonyms	(S)-(+)-1-Methyl-2',6'-pipecoloxylidide Monohydrochloride; (S)-Mepivacaine HCl; L-Mepivacaine Hydrochloride; (S)-2-(2,6-Dimethylphenyl)-1-methylpiperidinecarboxamide Hydrochloride; Carbocaine (S-enantiomer) Hydrochloride; Scandicain (S-enantiomer) Hydrochloride; CAS 34333-71-6
EINECS	Contact for details

Quality Control

Our (S)-(+)-Mepivacaine Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide full traceability and Certificates of Analysis (COA) detailing results for assay, chiral purity, related substances, residual solvents, and other critical parameters. Quality standards are aligned with ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition (Sulfated Ash)	≤0.1%
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.