Description

Saralasin is a potent and selective angiotensin II receptor antagonist, widely recognized for its role in cardiovascular and renal research. This compound is a critical tool for investigating the renin-angiotensin system (RAS), a key pathway regulating blood pressure and fluid balance. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on hypertension, heart failure, and related metabolic disorders.

Application

• Pharmacological Research: A standard reference antagonist for studying angiotensin II receptor (AT1) function and signaling pathways in vitro and in vivo.
• Cardiovascular Disease Models: Used to induce specific physiological states or to block angiotensin II effects in animal models of hypertension, cardiac hypertrophy, and heart failure.
• Renal Physiology Studies: Employed to investigate the role of the RAS in kidney function, sodium handling, and the pathophysiology of renal diseases.
• Drug Discovery & Development: Serves as a key comparator and tool compound in the screening and validation of new antihypertensive drug candidates.
• Biochemical Assays: Utilized in receptor binding assays and enzymatic studies to determine inhibitor potency and specificity.
• Academic & Educational Use: A fundamental reagent for teaching and advanced research in physiology, pharmacology, and medicinal chemistry.

Basic Information

Product Name	Saralasin
CAS No.	34273-10-4
Molecular Formula	C42H60N12O10
Molecular Weight	912.99 g/mol
Synonyms	Saralasin Acetate; [Sar¹,Ala⁸]-Angiotensin II; 1-Sarcosine-8-alanine-angiotensin II; P-113; Sarenin; NSC-329853; Angiotensin II, 1-sarcosine-8-alanine-
EINECS	Contact for details

Quality Control

Our Saralasin is produced and tested under strict quality management systems to ensure high purity and batch-to-batch consistency for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Assay (HPLC)	≥95.0%
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.