Description

Guanylyl Imidodiphosphate is a high-purity biochemical reagent, a non-hydrolyzable analog of GTP (guanosine triphosphate). This compound is essential for studying G-protein coupled receptor (GPCR) signaling pathways and other nucleotide-dependent enzymatic processes where stable activation is required. It is a critical tool for researchers and manufacturers in pharmaceutical development, biochemical research, and diagnostic assay production, providing reliable and consistent performance in sensitive applications.

Application

• Biochemical Research: Used as a stable GTP analog to study the activation and regulation of G-proteins, GTPases, and other nucleotide-binding proteins.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) assays to identify modulators of GPCR activity and other drug targets.
• Diagnostic Development: Serves as a key component in the development of diagnostic kits and assays that detect or quantify GTPase activity.
• Enzymology Studies: Utilized to investigate enzyme kinetics and mechanisms of action for ATP/GTP-dependent enzymes without interference from hydrolysis.
• Signal Transduction Research: A vital tool for elucidating intracellular signaling cascades and second messenger systems in cell biology.
• Academic & Institutional Labs: Fundamental reagent for teaching and advanced research in molecular biology and biochemistry.

Basic Information

Product Name	Guanylyl Imidodiphosphate
CAS No.	34273-04-6
Molecular Formula	C10H16N5O13P3
Molecular Weight	523.16 g/mol
Synonyms	GMP-PNP; Guanosine 5'-[β,γ-imido]triphosphate; Guanylyl imidodiphosphate tetra lithium salt; Gpp(NH)p; 5'-Guanylyl imidodiphosphate; Non-hydrolyzable GTP; β,γ-Imidoguanosine 5'-triphosphate; GTPγS analog
EINECS	Contact for details

Quality Control

Our Guanylyl Imidodiphosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the stringent requirements for research and diagnostic use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer solution
Biological Activity	Tested in standard GPCR activation assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.