Description

[(2R,3R,4S)-5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl ]Methyl Benzoate is a high-purity nucleoside derivative and a key protected intermediate in advanced pharmaceutical synthesis. This compound is critical for ensuring the precise stereochemistry and functional group integrity required in the production of complex antiviral and anticancer agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and scale-up of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of modified nucleoside analogs used in antiviral and anticancer drug discovery and development.
• Antiviral Pro-drug Synthesis: Serves as a protected precursor in the manufacturing chain for nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral medications.
• Oligonucleotide Chemistry: Used in the research-scale preparation of modified oligonucleotides for diagnostic applications and therapeutic antisense technologies.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies and metabolic pathway research involving nucleotide metabolism.
• Process Development: Essential for process chemistry teams optimizing large-scale, GMP-compliant synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	[(2R,3R,4S)-5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl ]Methyl Benzoate
CAS No.	34270-10-5
Molecular Formula	C17H17N3O7
Molecular Weight	375.34 g/mol
Synonyms	1-(2,3-Dihydroxy-4-[(benzoyloxy)methyl]tetrahydrofuran-5-yl)-4-aminopyrimidin-2-one; 5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl benzoate; Protected Cytidine Derivative; Cytidine 2',3'-O-Benzoyl Derivative; N4-Benzoyl-2',3'-O-dibenzoylcytidine (related intermediate); 1-[(2R,3R,4S)-3,4-Dihydroxy-5-[(benzoyloxy)methyl]oxolan-2-yl]-4-aminopyrimidin-2-one
EINECS	Contact for details

Quality Control

Our [(2R,3R,4S)-5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl ]Methyl Benzoate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (by Chiral HPLC)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.