Description

2'-O,3'-o-Isopropylidene-5'-Deoxy-5'-Azidoadenosine is a protected nucleoside derivative, a crucial intermediate in synthetic organic chemistry and pharmaceutical research. Its primary value lies in its functionalized structure, featuring an azido group at the 5'-position, which serves as a versatile handle for "click chemistry" reactions, particularly the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers developing novel nucleoside analogs, antisense oligonucleotides, and other bioconjugates for therapeutic and diagnostic applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Bioconjugation & Probe Development: The 5'-azido group enables efficient "click chemistry" for labeling oligonucleotides, proteins, or surfaces with fluorescent dyes, affinity tags, or other functional molecules.
• Antisense Oligonucleotide (ASO) Synthesis: Used in the preparation of modified oligonucleotides for research into gene silencing and therapeutic applications.
• Chemical Biology Research: A vital tool for studying nucleic acid structure, function, and interactions through site-specific modification.
• Polymer-Supported Synthesis: Employed in solid-phase synthesis for the automated production of oligonucleotide libraries.
• Diagnostic Reagent Precursor: Serves as a starting material for creating labeled nucleotides used in diagnostic assays and sequencing technologies.

Basic Information

Product Name	2'-O,3'-o-Isopropylidene-5'-Deoxy-5'-Azidoadenosine
CAS No.	34245-48-2
Molecular Formula	C13H16N8O4
Molecular Weight	348.32 g/mol
Synonyms	5'-Azido-5'-deoxy-2',3'-O-isopropylideneadenosine; 5'-Azido-2',3'-O-isopropylideneadenosine; 5'-Deoxy-5'-azido-2',3'-O-isopropylideneadenosine; 2',3'-O-Isopropylidene-5'-azido-5'-deoxyadenosine; 5'-Azido-5'-deoxy-2',3'-O-(1-methylethylidene)adenosine; N6-Amino-9-(5-azido-5-deoxy-2,3-O-isopropylidene-β-D-ribofuranosyl)purine; Adenosine, 5'-azido-5'-deoxy-2',3'-O-(1-methylethylidene)-
EINECS	Contact for details

Quality Control

Our 2'-O,3'-o-Isopropylidene-5'-Deoxy-5'-Azidoadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere for long-term stability. This compound is moisture-sensitive (hygroscopic) and should be handled in a dry environment to prevent decomposition. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.