Description

Guanosine Periodate Oxidized CAS NO 34240-06-7 is a chemically modified nucleoside derivative where the ribose sugar moiety of guanosine has been selectively oxidized by periodate. This modification is critical for introducing reactive aldehyde groups, enabling its use as a versatile biochemical cross-linking and conjugation reagent. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic industries for applications requiring precise biomolecular labeling and attachment.

Application

• Bioconjugation and Cross-linking: Key reagent for covalently linking biomolecules (e.g., proteins, antibodies, oligonucleotides) to surfaces, particles, or other molecules via the reactive aldehyde groups.
• Diagnostic Assay Development: Used in the manufacture and development of ELISA kits, lateral flow assays, and other immunoassays for immobilizing capture antibodies or antigens.
• Pharmaceutical Research: Employed in drug discovery for creating antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Nucleic Acid Labeling: Facilitates the introduction of tags (e.g., fluorescent dyes, biotin) onto oligonucleotides for detection and purification purposes.
• Biomaterial Functionalization: Used to modify polymers, hydrogels, and sensor surfaces with nucleoside motifs to enhance biocompatibility or create specific binding sites.
• Enzyme Immobilization: Aids in the stable attachment of enzymes to solid supports for biocatalysis and industrial enzyme applications.

Basic Information

Product Name	Guanosine Periodate Oxidized
CAS No.	34240-06-7
Molecular Formula	C10H11N5O6
Molecular Weight	297.23 g/mol
Synonyms	Periodate-Oxidized Guanosine; Guanosine, periodate-oxidized; 8-Oxoguanosine derivative (periodate-oxidized); 2-Amino-9-(1,2-dicarboxy-4,5-dihydroxyoxolan-3-yl)-1,9-dihydro-6H-purin-6-one; Oxidized Guanosine; Guanosine dialdehyde; Nucleoside cross-linker
EINECS	Contact for details

Quality Control

Our Guanosine Periodate Oxidized is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and functional group analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades, including research and bioconjugation grades, are available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Functional Group (Aldehyde)	Positive test
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.