Description

2'-(o-Methyl)-5-Iodouridine is a modified nucleoside derivative, specifically a halogenated uridine analog. This compound is of significant value in pharmaceutical research and development, particularly in the synthesis of novel antiviral and anticancer agents. It serves as a critical building block for medicinal chemists and researchers in the life sciences sector, enabling the exploration of structure-activity relationships and the development of targeted therapeutics. Its unique structure makes it essential for applications in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer drugs.
• Medicinal Chemistry Research: Used as a building block to study structure-activity relationships (SAR) and develop targeted therapeutic agents.
• Biochemical Probe Development: Employed in the creation of probes for studying nucleic acid metabolism and enzyme function.
• Antisense Oligonucleotide Synthesis: Can be incorporated into oligonucleotides to modulate their stability, binding affinity, and biological activity.
• Radiopharmaceutical Precursor: The iodine moiety provides potential for radiolabeling (e.g., with I-125 or I-131) for diagnostic or therapeutic applications.
• Academic & Institutional Research: Used in university and institutional labs for fundamental research in biochemistry and molecular biology.

Basic Information

Product Name	2'-(o-Methyl)-5-Iodouridine
CAS No.	34218-84-3
Molecular Formula	C10H13IN2O6
Molecular Weight	384.13 g/mol
Synonyms	5-Iodo-2'-O-methyluridine; 2'-O-Methyl-5-iodouridine; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-5-iodopyrimidine-2,4-dione; 5-Iodo-2'-O-methyluridine; 2'-OMe-5-Iodouridine; 5-I-2'-OMe-UR
EINECS	Contact for details

Quality Control

Our 2'-(o-Methyl)-5-Iodouridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.