Description

O(4)-Methyluridine CAS NO 34218-77-4 is a chemically modified nucleoside derivative where a methyl group is introduced at the O4 position of the uridine base. This specific modification is of significant interest in the fields of nucleic acid chemistry and medicinal research, as it can alter base-pairing properties and stability. It serves as a critical building block and research tool for scientists developing novel oligonucleotides, prodrugs, and exploring RNA biology. This compound is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Nucleic Acid Research: Used as a modified monomer in the synthesis of oligonucleotides to study structure-function relationships and RNA interference (RNAi) mechanisms.
• Antiviral/Anticancer Prodrug Development: Acts as a precursor or intermediate in the synthesis of nucleoside analog prodrugs targeting viral replication or cancer cell proliferation.
• Medicinal Chemistry: Serves as a key scaffold for the design and synthesis of novel therapeutic agents that modulate genetic expression.
• Biochemical Tool: Employed in enzymatic studies to investigate substrate specificity and the function of kinases, phosphorylases, and other nucleoside-metabolizing enzymes.
• Diagnostic Probe Synthesis: Incorporated into labeled probes for detecting specific RNA sequences in diagnostic assays.
• Academic & Industrial R&D: Fundamental research material in universities and corporate R&D labs for exploring new applications in epigenetics and chemical biology.

Basic Information

Product Name	O(4)-Methyluridine
CAS No.	34218-77-4
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	4-O-Methyluridine; 4-Methoxyuridine; Uridine, 4-methyl ether; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-methoxypyrimidin-2(1H)-one; 2'-Deoxy-4-O-methyluridine (common misnomer, verify structure); 4-OMe-Urd
EINECS	Contact for details

Quality Control

Our O(4)-Methyluridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality systems are designed to support research and development requiring high-purity, well-characterized biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.