Description

5,20-Dihydroxy-6,7-Epoxy-1-Oxo-5-Witha-2,24-Dienolide is a high-purity, bioactive withanolide derivative, a class of steroidal lactones known for their significant pharmacological potential. This compound is valued for its role as a critical reference standard and a key intermediate in advanced pharmaceutical research and development. It is primarily sought by research institutions and pharmaceutical companies focused on developing novel therapeutic agents, particularly in the fields of oncology, neurology, and immunomodulation.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of withanolides in drug discovery and quality control laboratories.
• Bioactive Compound Research: Serves as a lead molecule or intermediate in pharmacological studies investigating anti-cancer, neuroprotective, and anti-inflammatory activities.
• Natural Product Chemistry: Employed in the isolation, characterization, and synthesis of complex withanolides from plant sources like Withania somnifera (Ashwagandha).
• Analytical Method Development: Critical for calibrating instruments and validating analytical methods such as HPLC, LC-MS, and NMR in contract research organizations (CROs).
• Preclinical Studies: Utilized in in vitro and in vivo studies to establish proof-of-concept for new drug candidates.

Basic Information

Product Name	5,20-Dihydroxy-6,7-Epoxy-1-Oxo-5-Witha-2,24-Dienolide
CAS No.	34199-22-9
Molecular Formula	C28H38O6
Molecular Weight	470.60 g/mol
Synonyms	6,7-Epoxy-5,20-dihydroxy-1-oxowitha-2,24-dienolide; Withanolide D; (20S,22R)-5,20,27-Trihydroxy-1-oxo-6,7-epoxywitha-2,24-dienolide; 5,20-Dihydroxy-6,7-epoxy-1-oxowitha-2,24-dienolide; Witha-2,24-dienolide, 5,20-dihydroxy-6,7-epoxy-1-oxo-; 6,7-Epoxywithanolide D; Ashwagandha Lactone D
EINECS	Contact for details

Quality Control

Our 5,20-Dihydroxy-6,7-Epoxy-1-Oxo-5-Witha-2,24-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. The compound is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the product to reach room temperature in a sealed container before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.