Description

2,2'-Anhydro-1-(β-Arabinofuranosyl)-Orotic Acid CAS NO 33886-20-3 is a specialized nucleoside derivative, serving as a key intermediate in the synthesis of modified nucleic acids and antiviral compounds. Its value lies in its unique anhydro-arabinofuranosyl structure, which is critical for imparting specific biological activity and metabolic stability to final pharmaceutical agents. This high-purity intermediate is essential for research institutions and pharmaceutical manufacturers focused on developing novel antiviral therapies and nucleotide-based drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of antiviral nucleoside analogs and other therapeutic agents targeting viral replication.
• Antiviral Drug Research: Used in medicinal chemistry and preclinical research for the development of new treatments against DNA and RNA viruses.
• Nucleic Acid Chemistry: Serves as a modified precursor in oligonucleotide synthesis for creating probes and tools with enhanced stability.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism pathways.
• Process Development: Utilized in scaling up synthetic routes for active pharmaceutical ingredients (APIs) in cGMP manufacturing environments.

Basic Information

Product Name	2,2'-Anhydro-1-(β-Arabinofuranosyl)-Orotic Acid
CAS No.	33886-20-3
Molecular Formula	C10H10N2O7
Molecular Weight	270.20 g/mol
Synonyms	2,2'-Anhydro-1-β-D-arabinofuranosylorotic Acid; 1-(2,2'-Anhydro-β-D-arabinofuranosyl)orotic Acid; 2,2'-O-Cycloorotidine; NSC 154020; AAU; Anhydro-Ara-U; β-2,2'-Anhydro-arabinofuranosyluracil-6-carboxylic Acid; 1-(2,2'-Anhydro-β-D-arabinofuranosyl)-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic Acid
EINECS	Contact for details

Quality Control

We supply 2,2'-Anhydro-1-(β-Arabinofuranosyl)-Orotic Acid in high-purity grades suitable for pharmaceutical research and development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by validated methods (e.g., HPLC, NMR) are available upon request. We adhere to strict quality management principles to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.