Description

9-Fluoro-11B,17,21-Trihydroxy-16A-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate CAS NO 33755-46-3 is a synthetic corticosteroid derivative, specifically a fluorinated pregnadiene. This compound is a key pharmaceutical intermediate of significant commercial value, primarily used in the synthesis of potent topical anti-inflammatory and anti-pruritic medications. It is essential for manufacturers in the pharmaceutical and fine chemical sectors who require high-purity, reliable building blocks for advanced steroid synthesis.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of advanced corticosteroid APIs (Active Pharmaceutical Ingredients).
• Topical Corticosteroid Synthesis: Key building block for manufacturing potent dermatological creams and ointments used to treat eczema, psoriasis, and dermatitis.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry research for novel anti-inflammatory agents.
• Veterinary Medicine: Used in the development of topical treatments for inflammatory skin conditions in animals.
• Process Development: Employed by fine chemical companies for scaling up and optimizing steroid manufacturing processes.

Basic Information

Product Name	9-Fluoro-11B,17,21-Trihydroxy-16A-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate
CAS No.	33755-46-3
Molecular Formula	C27H37FO6
Molecular Weight	476.58 g/mol
Synonyms	Fluticasone 17-Valerate; Fluticasone Valerate EP Impurity C; 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-valerate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17-valerate; S 33,060; SQ 33,060; Fluticasone Propionate Related Compound C; Fluticasone Valerate Intermediate.
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11B,17,21-Trihydroxy-16A-Methylpregna-1,4-Diene-3,20-Dione 17-Valerate is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and structural identity suitable for pharmaceutical synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Ensure the storage area is well-ventilated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.