Description

Guanosine Tetraphosphate is a high-purity nucleotide derivative of significant biochemical and industrial interest. This compound serves as a critical building block and research tool in the study of cellular signaling, energy metabolism, and enzymatic processes. It is essential for manufacturers and research institutions in the pharmaceutical, biotechnology, and life science sectors requiring precise nucleotide analogs for advanced applications.

Application

• Biochemical Research & Development: Used as a substrate, cofactor, or inhibitor in enzymatic studies, particularly those involving GTP-binding proteins (G-proteins) and nucleotide-dependent kinases.
• Pharmaceutical Intermediates: Serves as a key synthetic precursor for novel antiviral or anticancer nucleotide-based drug candidates.
• Diagnostic Reagent Manufacturing: Incorporated into assay kits for monitoring cellular energy status (ATP/ADP/AMP ratios) and related metabolic pathways.
• Enzymology Studies: Employed to investigate the mechanisms of polymerases, synthetases, and other enzymes that utilize guanosine nucleotides.
• Cell Signaling Research: Acts as a tool compound to probe cyclic nucleotide-independent signaling cascades within cells.

Basic Information

Product Name	Guanosine Tetraphosphate
CAS No.	33503-72-9
Molecular Formula	C10H17N5O17P4
Molecular Weight	603.16 g/mol
Synonyms	Guanosine 5'-tetraphosphate; ppGpp; Guanosine 5'-diphosphate 3'-diphosphate; Magic spot I; MS I; Guanosine pentaphosphate (common misnomer); Gp4G (abbreviation); Guanosine-5'-triphosphate-3'-diphosphate
EINECS	Contact for details

Quality Control

Our Guanosine Tetraphosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LAL testing for bacterial endotoxins where applicable. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Bacterial Endotoxins (LAL)	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.