Description

Negamycin CAS NO 33404-78-3 is a unique aminoglycoside antibiotic known for its specific activity against Gram-negative bacteria. This compound is of significant interest in pharmaceutical research and development due to its distinct mechanism of action, which involves the inhibition of protein synthesis by binding to the bacterial ribosome. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in antimicrobial discovery, mechanism of action studies, and the development of novel therapeutic agents.

Application

• Antimicrobial Research: Serves as a critical reference standard and active compound in studies targeting Gram-negative bacterial infections.
• Mechanistic Studies: Used to investigate bacterial protein synthesis inhibition and ribosome function in microbiological research.
• Pharmaceutical Development: Acts as a lead compound or intermediate in the synthesis and development of new antibiotic classes.
• Biochemical Assays: Employed in in vitro screening assays to evaluate novel antimicrobial agents or resistance mechanisms.
• Academic Research: Utilized in university and institutional labs for fundamental studies in microbiology and medicinal chemistry.

Basic Information

Product Name	Negamycin
CAS No.	33404-78-3
Molecular Formula	C₁₄H₂₅N₅O₇
Molecular Weight	375.38 g/mol
Synonyms	Negamycin; Antibiotic X-5108; Antibiotic K-21; L-2-Amino-6-[(1S)-1-carboxy-3-[(2S,3S)-3,4-dihydroxy-1-methyl-2-pyrrolidinyl]propyl]aminohexanoic acid; (2S)-2-Amino-6-[[(1S)-1-carboxy-3-[(2S,3S)-3,4-dihydroxy-1-methyl-2-pyrrolidinyl]propyl]amino]hexanoic acid
EINECS	Contact for details

Quality Control

Our Negamycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assessment, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.