Description

3,6α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is a high-purity, silylated derivative of estradiol, designed for advanced synthetic chemistry and pharmaceutical research. This compound serves as a critical protected intermediate, enabling precise and efficient chemical transformations in the synthesis of complex steroid-based molecules. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of novel steroidal drugs and active pharmaceutical ingredients (APIs).
• Steroid Chemistry Research: Used in academic and industrial R&D for exploring new synthetic pathways and modifying the estradiol core structure.
• Process Chemistry: Employed in the development and scale-up of manufacturing processes for hormone-based therapeutics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Bioconjugation & Prodrug Development: The silyl protecting groups facilitate selective reactions for creating targeted drug delivery systems.

Basic Information

Product Name	3,6α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene
CAS No.	33287-47-7
Molecular Formula	C27H48O3Si3
Molecular Weight	505.93 g/mol
Synonyms	Estra-1,3,5(10)-triene-3,6α,17β-triol, tris(trimethylsilyl) ether; 3,6α,17β-Tris-O-(trimethylsilyl)estra-1,3,5(10)-triene; Tris(trimethylsiloxy)estratriene; 3,6α,17β-Tris(trimethylsiloxy)estra-1,3,5(10)-triene; Silylated Estradiol Derivative; TMS-Estradiol Derivative
EINECS	Contact for details

Quality Control

Our 3,6α,17β-Tris(Trimethylsiloxy)-1,3,5(10)-Estratriene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.