Description

Guanosine 2'-Diphosphoric Acid is a high-purity nucleotide derivative, a critical building block in biochemical research and pharmaceutical development. Its primary value lies in its role as a key intermediate for synthesizing modified nucleosides and nucleotides, which are essential for studying RNA metabolism, enzyme mechanisms, and developing antiviral or anticancer therapeutics. This compound is indispensable for researchers and manufacturers in the fields of pharmaceutical R&D, molecular biology, and diagnostic reagent production, where precise chemical structure and high purity are paramount for reliable experimental and commercial outcomes.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Diagnostic Reagent Manufacturing: Employed in the production of high-sensitivity assay kits for detecting specific enzymes or metabolic pathways.
• RNA Metabolism Studies: Acts as a tool compound to investigate RNA capping, splicing, and other post-transcriptional modification processes.
• Reference Standard: Utilized as an analytical standard in HPLC, LC-MS, or NMR for quality control and method validation in laboratory and production settings.
• Enzyme Cofactor Research: Applied in studies exploring the role of nucleotide cofactors in cellular signaling and energy transfer.

Basic Information

Product Name	Guanosine 2'-Diphosphoric Acid
CAS No.	33151-13-2
Molecular Formula	C₁₀H₁₅N₅O₁₁P₂
Molecular Weight	443.20 g/mol
Synonyms	2'-GDP; Guanosine-2'-diphosphate; 2'-Guanosine diphosphate; GDP-2'; 2'-O-Diphosphoguanosine; Guanosine 2'-pyrophosphate; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-[(hydroxy{[(phosphonooxy)phosphinoyl]oxy}methyl)oxolan-2-yl]-6-iminopurin-2-one
EINECS	Contact for details

Quality Control

Our Guanosine 2'-Diphosphoric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the stringent requirements of research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.