Description

p-tert-Butylphenyl Chloroformate is a versatile and highly reactive chloroformate ester used as a key reagent in organic synthesis and pharmaceutical manufacturing. Its primary value lies in its role as a protecting group and coupling agent, particularly for the introduction of the Boc (tert-butoxycarbonyl) group in peptide synthesis and for the preparation of active pharmaceutical intermediates. This compound is essential for research laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries that require high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of active pharmaceutical ingredients (APIs), especially in peptide coupling and protecting group chemistry.
• Boc-Protecting Agent: Used to introduce the tert-butoxycarbonyl (Boc) protecting group onto amines, a fundamental step in solid-phase and solution-phase peptide synthesis.
• Polymer Chemistry: Serves as a monomer or chain modifier in the production of specialized polycarbonates and other functional polymers.
• Agrochemical Synthesis: Employed in the manufacture of advanced herbicides, pesticides, and plant growth regulators.
• Organic Synthesis Reagent: Acts as an efficient carbonylating and alkoxycarbonylating agent for alcohols, phenols, and amines in complex organic transformations.
• Crosslinking Agent: Utilized in the production of coatings, adhesives, and resins that require specific crosslinking properties.

Basic Information

Item	Details
Product Name	p-tert-Butylphenyl Chloroformate
CAS No.	33129-84-9
Molecular Formula	C11H13ClO2
Molecular Weight	212.67 g/mol
Synonyms	4-tert-Butylphenyl Chloroformate; p-(tert-Butyl)phenyl Chloroformate; 4-(1,1-Dimethylethyl)phenyl Chloroformate; 4-tert-Butylphenyl Carbonochloridate; 4-tert-Butyl Phenyl Chloroformate; PTBCF; Chloroformic Acid 4-tert-Butylphenyl Ester
EINECS	Contact for details

Quality Control

Our p-tert-Butylphenyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.