Description

2',3'-o-Isopropylidene-5'-Oxo-8,5'-Cycloadenosine is a chemically modified nucleoside derivative, serving as a crucial synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in providing a protected and reactive scaffold for the targeted synthesis of novel adenosine analogs and cyclonucleosides with potential biological activity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical R&D, particularly for developing antiviral agents, enzyme inhibitors, and exploring novel nucleotide-based therapeutics.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel adenosine receptor ligands and modified nucleoside analogs.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Medicinal Chemistry: Serves as a precursor for creating cyclonucleoside libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Biochemical Tool Development: Utilized in the preparation of affinity probes, labeled nucleotides, and enzyme substrates for biochemical assays.
• Nucleotide Chemistry: Fundamental intermediate in academic and industrial research exploring the synthesis and properties of conformationally restricted nucleosides.

Basic Information

Product Name	2',3'-o-Isopropylidene-5'-Oxo-8,5'-Cycloadenosine
CAS No.	33066-26-1
Molecular Formula	C13H15N5O4
Molecular Weight	305.29 g/mol
Synonyms	8,5'-Cycloadenosine, 2',3'-O-isopropylidene-5'-oxo-; 5'-Oxo-8,5'-cycloadenosine 2',3'-acetonide; 2',3'-O-Isopropylidene-5'-oxo-8,5'-cycloadenosine; 8,5'-Anhydro-2',3'-O-isopropylidene-5'-deoxy-5'-oxoadenosine; Adenosine, 2',3'-O-(1-methylethylidene)-5'-oxo-8,5'-cyclo-
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylidene-5'-Oxo-8,5'-Cycloadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.