Description

Uridine Diphosphate n-Acetyl-D-Galactosamine, [Galactosamine-6-3H(N)] is a high-specific-activity, tritium-labeled nucleotide sugar essential for studying glycosylation pathways. This compound serves as a critical radiolabeled substrate for the precise investigation of galactosyltransferase and other glycosyltransferase enzyme activities. It is primarily utilized by researchers in pharmaceutical development, biochemistry, and glycobiology for tracer studies, enzyme kinetics, and metabolic pathway analysis.

Application

• Glycosyltransferase Enzyme Assays: Acts as a radiolabeled donor substrate for in vitro studies of enzyme kinetics, specificity, and inhibition.
• Glycoconjugate Biosynthesis Research: Used to trace and quantify the incorporation of GalNAc into glycoproteins, proteoglycans, and glycolipids.
• Metabolic Pathway Tracing: Enables the study of sugar nucleotide metabolism and flux in cellular systems.
• Drug Discovery Screening: Employed in high-throughput assays to identify potential inhibitors of glycosylation enzymes for therapeutic development.
• Biochemical Reaction Mechanism Studies: Provides a tool for elucidating the mechanisms of glycosyl transfer reactions.
• Quality Control for Enzyme Preparations: Serves as a standard substrate to assess the activity and purity of glycosyltransferase enzyme batches.

Basic Information

Item	Detail
Product Name	Uridine Diphosphate n-Acetyl-D-Galactosamine, [Galactosamine-6-3H(N)]
CAS No.	33044-38-1
Molecular Formula	C17H27N3O17P2 (Unlabeled parent compound)
Molecular Weight	607.36 g/mol (Unlabeled parent compound)
Synonyms	UDP-GalNAc, [6-3H]; UDP-N-acetyl-D-galactosamine, [Galactosamine-6-3H(N)]; UDP-α-D-GalNAc, tritiated; Uridine 5'-(α-D-N-acetylgalactosamine diphosphate), [6-3H]; UDP-α-D-N-acetylgalactosamine, [6-3H(N)]; Tritiated UDP-GalNAc; Sugar nucleotide, radiolabeled; Glycosyl donor substrate.
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled nucleotide sugars is produced and tested to meet the exacting standards required for life science research. Radiochemical purity and specific activity are rigorously confirmed using analytical techniques such as HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, purity, solvent composition, and analytical methods. Our quality system ensures reliable, reproducible performance in your critical assays.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at ≤ -20°C or as recommended on the specific product COA. Avoid repeated freeze-thaw cycles. Store in accordance with local regulations for radioactive materials.

Specification

Item	Specification
Appearance	Clear solution
Specific Activity	10-40 Ci/mmol (Contact for exact value)
Radiochemical Purity	≥ 95% (by HPLC)
Chemical Purity	≥ 90% (by HPLC, UV detection)
Concentration	0.1-1.0 mCi/mL in aqueous ethanol
Identification	Co-chromatography with reference standard

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.