Description

2'-Bromo-2'-Deoxy-5-Fluorouridine is a halogenated nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a valuable biochemical tool for studying nucleic acid metabolism and enzyme inhibition. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral and anticancer therapeutics. Our supply ensures high purity and batch-to-batch consistency, supporting reliable and reproducible scientific outcomes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and antineoplastic (anticancer) nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for thymidine kinase and other nucleoside-metabolizing enzymes.
• Antiviral Agent Development: Investigated for its potential activity against DNA viruses due to its structural similarity to thymidine.
• Radiopharmaceutical Precursor: Can serve as a precursor for the synthesis of radiolabeled compounds for diagnostic imaging or targeted radiotherapy.
• Mechanistic Studies: Employed to probe DNA synthesis pathways and the mechanisms of action of fluoropyrimidine-based drugs.
• Academic & Contract Research: Essential reagent for universities and CROs (Contract Research Organizations) conducting life science and medicinal chemistry research.

Basic Information

Product Name	2'-Bromo-2'-Deoxy-5-Fluorouridine
CAS No.	32791-82-5
Molecular Formula	C9H10BrFN2O5
Molecular Weight	325.09 g/mol
Synonyms	5-Fluoro-2'-bromo-2'-deoxyuridine; 2'-Bromo-5-fluoro-2'-deoxyuridine; 5-Fluoro-1-((2R,4S,5R)-4-bromo-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; BrdUrd-F; 2'-Bromo-2'-deoxy-5-fluorouridine; 5-Fluoro-2'-bromodeoxyuridine; 2'-Bromo-5-fluorodeoxyuridine; 32791-82-5
EINECS	Contact for details

Quality Control

Every batch of 2'-Bromo-2'-Deoxy-5-Fluorouridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.